Time：3:30-5:00 PM，Tues., Aug. 30th，2022

Host：Dr. Danyang He, PI of School of Life Sciences

Venue：E10-222, Yungu Compus （Onsite）; Room 312, Building 3, Yunqi Compus (Online)

Speaker:

Dr. Chuan Wu, Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute

Dr. Wu completed his M.D. at Shanghai Jiaotong University, School of Medicine. He further undertook his doctoral research training at Muenster University, Germany, focusing on T cell migration during inflammation and autoimmunity. Then, he did his post-doctoral training at Brigham and Women’s Hospital, Harvard Medical School, where he studied transcriptional regulation for T cell differentiation. In 2016, Dr. Wu joined the faculty at Brigham and Women’s Hospital,  Harvard Medical School as an Assistant Professor and then moved to NCI in 2017 as an Earl Stadtman Investigator, where he re-directed his research to focus on how neuro-immune crosstalk regulates mucosal barrier function. His lab is interested in studying the mechanisms of how neuro-immune interactions contribute to body physiology and pathophysiology, and developing new therapies for immune-mediated diseases. Main questions his lab investigating include:
1. Reciprocal regulations between mucosal barrier and microbiota.
2. Neuro-immune crosstalk for the mucosal homeostasis in lungs and gastrointestinal tract.
3. Identification of novel targets in the intestinal epithelium for IBD treatment.
Throughout his career, Dr. Wu has published many peer-reviewed manuscripts and review articles. His career aspirations are to understand the mechanisms of how neuro-immune interactions contribute to body physiology and pathophysiology, and to facilitate the development of new therapies for immune-mediated diseases.  

Abstract:

The intestinal epithelium represents the largest interface which protects the body from potential danger while sensing external milieu. Given that the gut also functions as a major endocrine organ, the efficient translation from environmental cues to neuroendocrine responses is essential for body physiology. By harboring large quantities of microbiota and immune cells, the intestinal tissue is filled with a variety of immune regulators. While certain receptors have been identified to detect different environmental stimuli such as microbial metabolites, irritants, mechanical stress, it is still unclear whether and how immune signals participate in gut sensation to enforce intestinal homeostasis and host defense. We are studying how immune signals integrate into neural regulation for gut sensation during intestinal homeostasis and inflammation.

Contact：

Wenyue Yu: yuwenyue@westlake.edu.cn

School of Life Sciences