Bing ZHANG, Ph.D.

School of Life Sciences

The Laboratory of Skin Stem Cells and Regeneration




Bing ZHANG, Ph.D.

School of Life Sciences

The Laboratory of Skin Stem Cells and Regeneration





Dr. Bing Zhang received his bachelor’s degree from Shandong University in 2007 and Ph.D. in Biochemistry from Case Western Reserve University in 2015. He was a postdoctoral fellow at Harvard Department of Stem Cell and Regenerative Biology between 2015 and 2020, studying skin stem cells and regeneration. He received Harvard Distinction in Teaching Award and Charles A. King Trust Postdoctoral Fellowship. Dr. Zhang is a principal investigator of Westlake University from September 2020. 



Adult stem cells play a central role in the regeneration and repair of our body systems. Using mammalian skin as a model system, we study the principles of cell-cell interactions among different cell types in development, regeneration and injury repair. Dr. Zhang’s academic achievements include

1. Identified a mechanism by which the growth of an epithelial tissue (the hair follicle) and a mesenchymal tissue (dermal adipocytes) can be coupled (Zhang et al., Gene and Development 2016), established a novel paradigm for studying the coupling of lineage behaviors in regeneration and diseases.

2. Identified a mechanism by which acute stress leads to a rapid depletion of melanocyte stem cells and hair graying (Zhang et al., Nature 2020), illustrated how an organismal-level neuronal activity can directly influence a tissue-level somatic stem cell population.

3. Developed new approaches and tools to study diverse cell types in the skin.

Our current research focus is to study

1. The mechanism and function of nerve–stem cell interaction;

2. How systemic factors of the body, such as stress and aging influence stem cell behaviors and tissue regeneration;

3. Mechanisms of mammalian skin and hair regeneration.


Representative Publications

1. Sekyu Choi, Bing Zhang, Sai Ma, Meryem Gonzalez-Celeiro, Daniel Stein, Xin Jin, Seung Tea Kim, Yuan-Lin Kang, Antoine Besnard, Amelie Rezza, Laura Grisanti, Jason Buenrostro, Michael Rendl, Matthias Nahrendorf, Amar Sahay and Ya-Chieh Hsu (2021) The stress hormone corticosterone governs hair follicle stem cell quiescence by suppressing a dermal niche activator Gas6. Nature 593.

2. Bing Zhang#, Megan He, Inbal Rachmin, Xiaoling Yu, Seungtea Kim, David E Fisher and Ya-Chieh Hsu# (2021) Melanocortin 1 receptor is dispensable for acute stress induced hair graying in mice. Experimental Dermatology Apr;30(4):572-577. (# Corresponding authors)

3. Inbal Rachmin, Ju Hee Lee, Bing Zhang, James Sefton, Inhee Jung, Young In Lee, Ya-Chieh Hsu and David E. Fisher (2021) Stress-associated ectopic differentiation of melanocyte stem cells and ORS amelanotic melanocytes in an ex vivo human hair follicle model. Experimental Dermatology, Apr;30(4):578-587.

4. Sai Ma, Bing Zhang, Lindsay LaFave, Zachary Chiang, Yan Hu, Jiarui Ding, Alison Brack, Vinay K Kartha, Travis Law, Caleb Lareau, Ya-Chieh Hsu, Aviv Regev, Jason D Buenrostro (2020) Chromatin potential identified by shared single cell profiling of RNA and chromatin. Cell 183, 1103-1116.e20.

5. Yulia Shwartz, Meryem Gonzalez-Celeiro, Chih-Lung Chen, H. Amalia Pasolli, Shu-Hsien Sheu, Sabrina Mai-Yi Fan, Farnaz Shamsi, Steven Assaad, Edrick Tai-Yu Lin, Bing Zhang, Pai-Chi Tsai, Megan He, Yu-Hua Tseng, Sung-Jan Lin and Ya-Chieh Hsu (2020) Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell 182, 578-593.e19.

6. Bing Zhang, Sai Ma, Inbal Rachmin, Megan He, Pankaj Baral, Sekyu Choi, William A. Gonçalves, Yulia Shwartz, Eva M. Fast, Yiqun Su, Leonard I. Zon, Aviv Regev, Jason D. Buenrostro, Thiago M. Cunha, Isaac M. Chiu, David E. Fisher and Ya-Chieh Hsu (2020)Hyperactivation of Sympathetic Nerves Drives Melanocyte Stem Cell Depletion. Nature 577, 676–681.

7. Bing Zhang*, Megan He* and Ya-Chieh Hsu (2020) FACS Isolation of Melanocyte Stem Cells from Mouse Skin. Protocol Exchange: DOI 10.21203/rs.2.17987/v1 (*Co-first author).

8.Alex J. Gooding, Bing Zhang, Lalith Gunawardane, Abigail Beard, Saba Valadkhan and William P. Schiemann (2018) The lncRNA BORG Facilitates the Survival and Chemoresistance of Triple-Negative Breast Cancers. Oncogene 38: 2020-2041.

9. Alex J. Gooding, Bing Zhang, Fereshteh K. Jahanbani, Hannah L. Gilmore, Jenny C. Chang, Saba Valadkhan and William P. Schiemann (2017) The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence. Scientific Reports 7: 12698.

10. Bing Zhang and Ya-Chieh Hsu (2017)Emerging Roles of Transit-Amplifying Cells in Tissue Regeneration and Cancer. WIREs Developmental Biology 6: e282.

11. Bing Zhang*, Pai-Chi Tsai*, Meryem Gonzalez-Celeiro, Oliver Chung, Benjamin Boumard, Carolina N. Perdigoto, Elena Ezhkova and Ya-Chieh Hsu (2016)Hair Follicles’ Transit Amplifying Cells Govern Concurrent Dermal Adipocyte Production through Sonic Hedgehog. Genes and Development 30: 2325-2338 (*Co-first author).

12. Meryem Gonzalez-Celeiro*, Bing Zhang* and Ya-Chieh Hsu (2016) Fate by Chance, not by Choice: Epidermal Stem Cells Caught in Live. Cell Stem Cell 19: 8-10 (*Co-first author).

13. Hongmei Mou, Vladimir Vinarsky, Purushothama RaoTata, Karissa Brazauskas, Soon H.Choi, Adrianne K.Crooke, Bing Zhang, George M.Solomon, Brett Turner, Hermann Bihler, Jan Harrington, Allen Lapey, Colleen Channick, Colleen Keyes, Adam Freund, Steven Artandi, Martin Mense, Steven Rowe, John F.Engelhardt, Ya-Chieh Hsu and Jayaraj Rajagopal (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell19, 217-231.

14. Bing Zhang, Lalith Gunawardane, Farshad Niazi, Fereshteh Jahanbani, Xin Chen and Saba Valadkhan (2014) A Novel RNA Motif Mediates the Nuclear Localization of a Long Non-Coding RNA. Molecular and Cell Biology 34: 2318-2329.

15.Yasaman Jaladat, Bing Zhang, Afshin Mohammadi and Saba Valadkhan (2011) Splicing of an intervening sequence by protein free human snRNAs.RNA Biology 8: 372-377.



We currently have several openings for graduate students, research assistants & postdocs. Please submit your CV or resume through email if interested.