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Jie-Min JIA, Ph.D.
School of Life Sciences
Laboratory of Neurovascular Biology
"Completely believing in a book is worse than reading no book. I sincerely hope WIAS could be the place where people can have independent and critical thinking, where people can create authority and challenge the authority at spirally developing pace, where people can get the science close to truth as much as possible."
Biography
Dr. Jie-Min Jia is an assistant professor in Westlake University at Hangzhou. She received her Bachelor's Degree from Zhejiang Normal University in 2002 and Ph.D. degree in Neurobiology at Institute of Neuroscience in Chinese Academy of Sciences in 2008. Following a five-year postdoctoral research period at National Institutes of Health, she joined UTSW as an assistant instructor in 2014. In 2017, she joined Westlake University as an independent principle investigator. Dr. Jia received Di-Ao Award in 2009.
Research
Dr. Jie-Min Jia's research provided important mechanisms for neural circuitry homeostasis, elucidated spine pathology for schizophrenia and created a novel focal ischemia animal model that is compatible with real-time live imaging and suitable for newly born mice. She is one of the most pioneers who utilize two-photon microscopy to study neurovascular unit in stroke. Her state-of-art skill uncovered a new vascular pathology in stroke and advanced the mechanistic understanding of neurovascular unit damage and repair under stroke. Dr. Jia opened a new way to study neonatal stroke pathology by combining genetics and live-imaging technology. Dr. Jia received Di-AO prize from Chinese Academy of Sciences and Director prize from Institute of Neuroscience, Shanghai. She has been frequently invited to give a talk about her research by many pioneer research agencies， such as Scientific committee of National Institute of Mental Health at National Institutes of Health.
Representative Publications
1. Jia JM, Chowdary PD, Gao X, Ci B, Li W, Mulgaonkar A, Plautz EJ, Hassan G, Kumar A, Stowe AM, Yang SH, Zhou W, Sun X, Cui B & Ge WP (2017) Control of Cerebral Ischemia with Magnetic Nanoparticles. Nature Methods 14(2): 160-166.
2. Jia JM, Hu Z, Nordman J, Li Z (2014) The Schizophrenia Susceptibility Gene Dysbindin Regulates Dendritic Spine Dynamics. Journal of Neuroscience 34 (41): 13725-13736.
3. Han MH, Jiao S, Jia JM, Chen Y, Chen C, Gucek M, Markey S, Li Z (2013) The Novel Caspase-3 Substrate Gap 43 Is Involved in AMPA Receptor Endocytosis and Long-Term Depression. Molecular and Cellular Proteomics 12 (12): 3719-3731.
4. Jia JM, Zhao J, Hu Z, Linberg D, Li Z (2013). Age-Dependent Regulation of Synaptic Connections by Dopamine D2 Receptors. Nature Neuroscience 16 (11): 1627-1636.
5. Jia JM, Arnheiter H, Li Z (2010) Schizophrenia Susceptibility Gene DISC1 Regulates Dendritic Spines through Kalirin-7 and Rac1. Cell Science Review 6 (4): 13-18.
6. Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M (2010) Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization. Cell 141 (5): 859-871.
7. Chen M, Chen Q, Cheng XW, Lu TJ, Liu HX, Jia JM, Zhang C, Xu L, Xiong ZQ (2009) Zn2+ Mediates Ischemia-Induced Impairment of The Ubiquitin-Proteasome System in The Rat Hippocampus. Journal of Neurochemistry 111 (5): 1094-1103.
8. Jia JM, Chen Q, Zhou Y, Miao S, Zheng J, Zhang C, Xiong ZQ (2008) Brain-Derived Neurotrophic Factor-Tropomyosin-Related Kinase B Signaling Contributes to Activity-Dependent Changes in Synaptic Proteins. Journal of Biological Chemistry 283 (30): 21242-50.
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