俞晓春博士

Xiaochun Yu, M.D. Ph. D.

生命科学学院

基因组不稳定性和癌症发生发展实验室

联系

邮箱: yuxiaochun@westlake.edu.cn

网站:

俞晓春博士

Xiaochun Yu, M.D. Ph. D.

生命科学学院

基因组不稳定性和癌症发生发展实验室

联系

邮箱: yuxiaochun@westlake.edu.cn

网站:


个人简介


1991-1996年 北京医科大学,医学士

1996-2002年 日本久留米大学,细胞生物学博士

2002-2006年 美国Mayo Clinic 博士后

2006-2015年 美国密歇根大学医学院内科系助理教授,副教授,正教授

2015-2020年 美国希望之城贝克曼研究所正教授

2020年起       西湖大学生命科学学院正教授


学术成果


俞晓春教授长期致力于DNA损伤修复机制和癌症发生发展的研究。众所周知细胞内基因组随时面临着来自体外和体内的各种损伤因素的挑战,如果 DNA 的损伤得不到及时修复,则会导致细胞的细胞周期紊乱、细胞凋亡、癌症发生等等恶性结果。因此,如何正确完成 DNA 的损伤修复并维持基因组的稳定性,对于细胞的存活进而防止肿瘤等重大疾病的发生起着至关重要的作用。因而,与此相关的分子机制研究是 DNA 损伤修复生物学的核心内容,对于肿瘤的诊断、抗肿瘤药物的设计等都具有重要的理论指导意义。其学术成果特别对家族性乳腺癌,卵巢癌,胰腺癌和白血病检测和治疗产生巨大的影响。曾获2006年美国卵巢癌研究协会独立研究员奖,2007年美国癌症研究协会 (AACR)Susan G. Komen乳腺癌学者奖,2008年美国癌症协会(ACS)学者奖,2010年美国国防部乳腺癌项目划时代学者奖,2014年白血病淋巴癌协会学者奖,2018年Tower癌症研究基金会学者奖,2019年胰腺癌联盟转化医学研究奖,2019年Taub癌症研究基金会白血病研究奖。


代表论文


1. Kim, H., Chen, J. * and Yu, X. * (2007). Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responses. Science, 316, 1202-1205. (* co-corresponding authors).

2. Liu, Z., Wu, J., and Yu, X. (2007). CCDC98 targets BRCA1 to DNA damage sites. Nature Structural and Molecular Biology, 14, 716-720.

3. Huen, M., Grant, R., Manke, I., Minn, K., Yu, X.*, Yaffe, M.* and Chen, J.* (2007). The E3 ubiquitin ligase RNF8 propagates the DNA damage signal via an ubiquitin-dependent signaling pathway. Cell, 131, 901-914. (*co-corresponding authors)

4. Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B. * and Yu, X. * (2009) PALB2 links BRCA1 and BRCA2 in the DNA damage response. Current Biology, 19: 524-529. (* co-corresponding authors) 

5. Lu, L.Y., Wu, J., Ye, L. Gavrilina, G.B., Saunders, T.L. and Yu, X. (2010). RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell. 18, 371-384.

6. Zhang, F. and Yu, X. (2011). WAC, a partner of RNF20/40 complex, regulates histone H2B ubiquitination and gene transcription. Molecular Cell. 41, 384-397.

7. Wu, J., Chen, Y., Lu, L.Y., Wu, Y., Paulsen, M.T., Ljungman, M., Ferguson, D.O. and Yu, X. (2011). Chfr and RNF8 synergistically regulate ATM activation. Nature Structural and Molecular Biology. 18: 761-768.

8. Chen, Q., Chen, Y., Bian, C., Fujiki, R. and Yu, X. (2013) TET2 promotes histone O-GlcNacylation during gene transcription. Nature 493:561-564.

9. Ma, T., Chen, Y., Zhang, F., Yang, C-Y., Wang, S. and Yu, X. (2013) RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Molecular Cell. 49: 897-907.

10. Li, M. and Yu, X. (2013) Function of BRCA1 in the DNA damage response is mediated by ADPribosylation. Cancer Cell. 23:693-704.

11. Lu, L, Korakavi, G., Kuang, H. and Yu, X. (2013) Distinct DNA damage responses on male meiotic sex Chromosomes. Nature Communications. 3015.

12. Li, M., Lu, L., Yang, C., Wang, S. and Yu, X. (2013) The FHA and BRCT domains recognize ADPribosylation during DNA damage response. Genes&Development. 27: 1752-1768.

13. Chen, Y., Chen, Q., McEachin, R.C., Cavalcoli J.D. and Yu, X. (2014) H2A.B facilitates transcription elongation at methylated CpG loci. Genome Research.24:570-579.

14. Zhang, F., Chen, Y., Li, M. and Yu, X. (2014) The OB-fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response. Proceedings of the National Academy of Sciences 111:7278-7283.

15. Li M, Chen Q, Ma T, and Yu X. (2017) Targeting reactive nitrogen species suppresses hereditary pancreatic cancer Proceedings of the National Academy of Sciences 114:7106-7111. 

16. Wang J, Yuan Z, Cui Y, Xie R, Wang M, Ma Y, Yu X* and Liu X.* (2018) Structure basis for the inhibition of the methyl-lysine binding function of 53BP1 by NUDT16L1/TIRR. (* co-corresponding authors) Nature Communications. 9:2689.

17. Chen Q, Kassab MA, Dantzer F and Yu X. (2018) PARP2 mediates branched poly-ADP-ribosylation in response to DNA damage. Nature Communications. 9: 3233.

18. Bian C, Zhang C, Vyas A, Chen S-H, Liu C, Luo T and Yu X. (2019) NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nature Communications.10:693.

19. Chen S-H and Yu X (2019) Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Science Advances. 5:eaav4340.

20. Singh AK, Zhao B, Wang X, Li H, Qin H, Wu X, Ma Y, Horne D and Yu X (2020) Selective targeting of TET catalytic domain promotes somatic cell reprogramming. Proceedings of the National Academy of Sciences 117:3621-3626.


联系方式


电子邮箱:yuxiaochun@westlake.edu.cn